Personal Data

Name

Nima Razzaghi-Asl

Field of specialization

Medicinal Chemistry  
Academic rank Associate professor
Email n.razzaghi@pharmacy.arums.ac.ir
Phone number

Internal number: +98 45 335 224 37-39 (137)

 (Update: April 2018)

Degree

Field of specialization

Name of institution attended

Year of graduation

PhD

Medicinal Chemistry

Faculty of Pharmacy, Shiraz University of Medical Sciences

2013

MSc

Analytical Chemistry

Faculty of Chemistry, Amir Kabir University of Technology, Tehran Polytechnique

2003

BSc

Applied Chemistry

Faculty of Science, Tehran University

2000

 

Course

Title of thesis

Supervisors

Thesis score

PhD

Synthesis, molecular modeling & biological evaluation of novel non-peptidic dihydropyridine structures as BACE-1 inhibitors

Dr. Ramin Miri (Full Professor), Dr. Katayoun Javidnia (Full Professor)
Dr. Omidreza Firuzi (Associate Professor), Dr. Bahram Hemmateenejad (Full Professor)                       

 20

MSc

Analytical applications of Piroxicam    

Dr.Mohammad Edrissi (Full Professor)      

 19.5

 

Title

Year

The Potential of Natural Product vs Neurodegenerative Disorders: In silico Study of Artoflavanocoumarin as BACE-1 Inhibitor
N Razzaghi-Asl, Adibe Karimi, Ahmad Ebadi
Computational Biology and Chemistry, 77, 307-317

2018

Molecular modeling of indeno[1,2-b]quinoline-9,11-diones as cytotoxic agents
R Miri, F Bohlooli, N Razzaghi-Asl, A Ebadi
Iranian Journal of Pharmaceutical Research, 17(4), 1249-1262

2018

Structural Insight into Binding Mode of 9-Hydroxy Aristolochic Acid, Diclofenac and Indomethacin to PLA2
M Ebrahimi, O Firuzi, R Miri, N Razzaghi-Asl, A Ebadi
Interdisciplinary Sciences: Computational Life Sciences, 10(2), 400-410

2018

Molecular Modeling of Drug-Albumin Interactions: A case Study on Antifungal Agents
R Mamizadeh, N Razzaghi-Asl
Journal of Ardabil University of Medical Sciences, 18(2), 173-190

2018

Insights into the Structural/Conformational Requirements of Cytotoxic Oxadiazoles as Potential Chemotherapeutic Target Binding Agents
Radin Alikhani, N Razzaghi-Asl, Ali Ramazani, Zahra Hosseinzadeh
Journal of Molecular Structure, 1164, 9-22

2018

Identification of COX-2 inhibitors via structure-based virtual screening and molecular dynamics simulation
N Razzaghi-Asl, Sahar Mirzayi, Karim Mahnam, Saghi Sepehri
Journal of  Molecular Graphics and Modelling, 83, 138-152

2018

In silico analysis of a few dietary phytochemicals as potential tumor chemo-sensitizers
Reza Mamizadeh, Zahra Hosseinzadeh, N Razzaghi-Asl, Ali Ramazani
Structural Chemistry, 29(4), 1139-1151

2018

Virtual screening of some heterocyclic structures toward novel antibacterial agents
ZS Hosseini, MR Housaindokht, N Razzaghi-Asl, R Miri
Journal of the Iranian Chemical Society, 15(3), 621–628

2018

Design, synthesis, biological assessment and molecular docking studies of new 2-aminoimidazole-quinoxaline hybrids as potential anticancer agents
Z Ghanbarimasir, A Bekhradni, K Morteza-Semnani, A Rafiei, N Razzaghi-Asl, M Kardan
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 194, 21-25

2018

An Overview on Chemistry and Biological Importance of Pyrrolidinone
Z Hosseinzadeh, A Ramazani, K Hosseinzadeh, N Razzaghi-Asl, F Gouranlou
Current Organic Synthesis, 15(02), 166-178

2018

Structural Insight into Binding Mode of 9-Hydroxy Aristolochic Acid, Diclofenac and Indomethacin to PLA2
M Ebrahimi, O Firuzi, R Miri, N Razzaghi-Asl, A Ebadi
Interdisciplinary Sciences: Computational Life Sciences, 10(2), 400-410

2018

Molecular Modeling of Human CCR2 Receptor within POPC Lipid Bilayer
A Ebadi, D Dastan, M Azami, A Karimi, N Razzaghi-Asl
Structural Chemistry 28 (3), 849-857

2017

Synthesis and toxicity assessment of 3-oxobutanamides against human lymphocytes and isolated mitochondria
N Razzaghi-Asl, E Seydi, R Alikhani, S Rezvani, R Miri, A Salimi
Environmental Toxicology and Pharmacology 51, 71-84

2017

Effect of organic co-solvents in the evaluation of the hydroxyl radical scavenging activity by the 2-deoxyribose degradation assay: The paradigmatic case of α-lipoic acid
A Brizzolari, GM Campisi, E Santaniello, N Razzaghi-Asl, L Saso, MC Foti
Biophysical chemistry 220, 1-6

2017

Response surface methodology in drug design: A case study on docking analysis of a potent antifungal fluconazole
F Bohlooli, S Sepehri, N Razzaghi-Asl
Computational Biology and Chemistry, 67, 158-173

2017

Dabco containing acidic poly (ionic liquid): An efficient catalyst for the one-pot Preparation of 2, 3-dihydroquinazoline-4 (1H)-ones
Mohammad Kazem Mohammadi, Seyyed Jafar Saghanezhad, N Razzaghi-asl
Bulletin of the Chemical Society of Ethiopia, 31(3), 535-544

2017

Hypoglycemic activity of curcumin synthetic analogues in alloxan-induced diabetic rats
KK Das, N Razzaghi-Asl, SN Tikare, R Di Santo, R Costi, A Messore, L Pescatori, G Cuzzucoli Crucitti, J G Jargar, S A Dhundasi, L Saso
Journal of enzyme inhibition and medicinal chemistry 31 (1), 99-105

2016

Assessment of the Cytotoxic Effect of a Series of 1, 4-Dihydropyridine Derivatives Against Human Cancer Cells
N Razzaghi-Asl, R Miri, O Firuzi
Iranian journal of pharmaceutical research: IJPR 15 (3), 413

2016

Inhibition of Alzheimer’s BACE-1 by 2, 6-dialkyl-4-chromon-3-yl-1, 4-dihydropyridine-3, 5-dicarboxylates
N Razzaghi-Asl, N Aggarwal, S Srivastava, VS Parmar, AK Prasad, R Miri, L Saso, O Firuzi
Medicinal Chemistry Research 24 (8), 3230-3241

2015

Detailed atomistic molecular modeling of a potent type ΙΙ p38α inhibitor
SA Ebadi, N Razzaghi-Asl, M Khoshneviszadeh, R Miri
Structural Chemistry 26 (4), 1125-1137

2015

Quantum chemical analysis of potential anti-Parkinson agents
N Razzaghi-Asl, S Shahabipour, A Ebadi, A Bagheri
Journal of Chemical Sciences 127 (7), 1211-1220

2015

Molecular docking and quantum mechanical studies on biflavonoid structures as BACE-1 inhibitors
N Razzaghi-Asl, S Sepehri, A Ebadi, R Miri, S Shahabipour
Structural Chemistry 26 (2), 607-621

2015

Inhibitors of Alzheimer’s BACE-1 with 3, 5-bis-N-(aryl/heteroaryl) carbamoyl-4-aryl-1, 4-dihydropyridine structure
R Miri, O Firuzi, N Razzaghi-Asl, K Javidnia, N Edraki
Archives of pharmacal research 38 (4), 456-469

2015

Novel 9-(alkylthio)-acenaphtho[1,2-e]-1,2,4-triazine derivatives: synthesis, cytotoxic activity and molecular docking studies on B-cell lymphoma 2 (Bcl-2)
MK Mohammadi, O Firuzi, M Khoshneviszadeh, N Razzaghi-Asl, S Sepehri
DARU Journal of Pharmaceutical Sciences 22 (1), 2

2014

A new insight into computational molecular design: A case study on BACE-1 inhibitors
N Razzaghi-Asl, B Hemmateenejad, A Ebadi, S Shahabipour, R Miri
Journal of Computational Methods in Sciences and Engineering 14 (4, 5), 315-325

2014

Response surface strategy in the synthesis of Fe3O4 nanoparticles
N Khalighyan, N Hooshmand, N Razzaghi-Asl, K Zare, R Miri
International Journal of Nano Dimension 5 (5), 421-430

2014

Effect of Biomolecular Conformation on Docking Simulation: A Case Study on a Potent HIV-1 Protease Inhibitor
N Razzaghi-Asl, Saghi Sepehri, Ahmad Ebadi, Ramin Miri
Iranian Journal of Pharmaceutical Research, 14(3): 785–802

2014

Antioxidant properties of hydroxycinnamic acids: a review of structure-activity relationships
N Razzaghi-Asl, J Garrido, H Khazraei, F Borges, O Firuzi
Current medicinal chemistry 20 (36), 4436-4450

2013

Design and synthesis of novel 3, 5-bis-N-(aryl/heteroaryl) carbamoyl-4-aryl-1, 4-dihydropyridines as small molecule BACE-1 inhibitors
N Razzaghi-Asl, O Firuzi, B Hemmateenejad, K Javidnia, N Edraki, R Miri
Bioorganic & medicinal chemistry 21 (22), 6893-6909

2013

Ab initio modeling of a potent isophthalamide-based BACE-1 inhibitor: amino acid decomposition analysis
N Razzaghi-Asl, A Ebadi, N Edraki, S Shahabipour, R Miri
Medicinal Chemistry Research 22 (7), 3259-3269

2013

Fragment-based Binding Efficiency Indices in Bioactive Molecular Design: A Computational Approach to BACE-1 Inhibitors (2013-3) Structure-based Binding Efficiency Indices for BACE-1 Inhibitors
N Razzaghi-Asl, A Ebadi, N Edraki, S Shahabipour, R Miri
Iranian Journal of Pharmaceutical Research, 12(3): 423–436

2013

Comparative amino acid decomposition analysis of potent type I p38α inhibitors
A Ebadi, N Razzaghi-Asl, M Khoshneviszadeh, R Miri
DARU Journal of Pharmaceutical Sciences 21 (1), 41

2013

Synthesis and antiproliferative activity evaluation of imidazole-based indeno [1, 2-b] quinoline-9, 11-dione derivatives
H Sarkarzadeh, R Miri, O Firuzi, M Amini, N Razzaghi-Asl, N Edraki, A Shafiee
Archives of pharmacal research 36 (4), 436-447

2013

QM study and conformational analysis of an isatin Schiff base as a potential cytotoxic agent
R Miri, N Razzaghi-asl, MK Mohammadi
Journal of molecular modeling 19 (2), 727-735

2013

Synthesis, biological activity and docking study of some new isatin Schiff base derivatives
J Azizian, MK Mohammadi, O Firuzi, N Razzaghi-asl, R Miri
Medicinal Chemistry Research 21 (11), 3730-3740

2012

Response surface methodology in docking study of small molecule BACE-1 inhibitors
N Razzaghi-Asl, A Ebadi, N Edraki, A Mehdipour, S Shahabipour, R Miri
Journal of molecular modeling 18 (10), 4567-4576

2012

Ab initio and conformational analysis of a potent VEGFR-2 inhibitor: A case study on Motesanib
A Ebadi, N Razzaghi-Asl, S Shahabipour, R Miri
Iranian Journal of Pharmaceutical Research, 13(2): 405–415

2012

Theoretical binding efficiencies in bioactive molecular design: A case study on BACE-1 inhibitors
N Razzaghi-Asl, R Miri, A Ebadi, N Edraki
Research in Pharmaceutical Sciences 7 (5), S614

2012

Factor Effect estimation in Ciprofloxacin-Iron Interaction
M Edrissi, N Razzaghi-Asl, S Dargahi
International Journal of Research in Chemistry and Environment 2 (1), 242-250

2012

Removal of hazardous reactive blue 19 dye from aqueous solution by agricultural waste
M Abassi, N Razzaghi-Asl
J. Iran. Chem. Res 2, 221-230

2009

Interaction of mefenamic acid with cobalt (II) ions in aqueous media: evaluation via classic and response surface methods
M Edrissi, N Razzaghi-Asl, B Madjidi
Turkish Journal of Chemistry 32 (4), 505-519

2008

Sonochemical degradation of Basic Blue 41 dye assisted by nanoTiO 2 and H 2 O 2
M Abbasi, N Razzaghi-Asl
Journal of hazardous materials 153 (3), 942-947

2008

Modeling of Interaction of Humic Acid with Some Heavy Metals in Aqueous Media with Response Surface Method
N Razzaghi-Asl, M Abbasi, F Naghizadeh, S Hosseini
Invited Talks: MV Diudea, 276

2008

Complexation of iron with piroxicam: evaluation via response surface methodology
M Edrissi, N Razzaghi-Asl
Acta chimica slovenica 54 (4), 825-833

2007

Effect of gamma irradiation on chemical properties of saffron pigments
N Rastkari, N Razzaghi-Asl, L Afarin, R Alemi, R Ahmadkhaniha
II International Symposium on Saffron Biology and Technology 739, 451-453

2006

Determination of the stability constant of Cobalt (II) - Piroxicam Complex by Spectrophotometery
M Edrissi, N Razzaghi-Asl, O Moradi
Journal of Physical and Theoretical Chemistry 1, 51-56

2004

 

 

 

 

 

No. Book title / Colleagues Type of work Publisher Date of pub.
1 Organic Chemistry Problems, N. Razzaghi-Asl, A. Seraj Yaghoobi, T. Selk Gaffari, B. Farhangi Codification Shiran Negar (Ardabil-Iran) 2016

2

Organic Chemistry for Pharmacy Students, N. Razzaghi-Asl Compilation Navid (Shiraz-Iran) 2012
3 Advanced Methods in Organic Synthesis, M.K. Mohammadi, N. Razzaghi-Asl Translation Isalamic Azad University of Ahvaz 2014
4 Chemistry of Functional Groups, S. Rasouli,N. Razzaghi-Asl, N. Rastkari Translation Nagsh Bayan
(Tehran-Iran)
2008

 

  •  Research Projects
No.

Title

Institute

Approval
year

completion
year

Implementation
plan

1

Synthesis, anti-cancer activity, antibacterial effect and molecular modeling of
3,5-bis-N-(aryl) carbamoyl-4-aryl-1,4-dihydropyridine derivatives

Ardabil university of Medical Sciences

2014

2017

Executor

2

Synthesis, molecular modeling and biological assessment of novel non-peptidic
dihydropyridines as BACE-1 blocking agents (I)

Scientific and technological department of
presidential office
(Iran National Science Foundation)

2010

2013

Main co-worker

 

  • Dissertations
No.

Title

Degree / Field University / School

Implementation
plan

Year of thesis defense

1 Synthesis, characterization and molecular modeling of new Xanthine Oxidase inhibitors Pharm.D Tabriz Faculty of Pharmacy Advisor 2017
2 Synthesis, characterization and investigating the toxicity of some of the new pyridine derivatives Pharm.D Tabriz Faculty of Pharmacy Advisor 2017
3 Synthesis, biological evaluation and molecular modeling study of quinolone-based thiadizoles as potential inhibitors of human topoisomerase II for cancer chemotherapy PhD / Medicinal Chemistry  Sari School of Pharmacy Supervisor 2 In progress

4

Molecular docking simulation and biological evaluation of novel quinoxalin-2-amino imidazole derivatives with potential cytotoxic effect

PhD / Medicinal Chemistry  Sari School of Pharmacy  Advisor In progress

5

Virtual screening and design of new 1-4 dihydropyridine structures as
antibacterial agents

 PhD / Physical Chemistry Ferdowsi University of Mashhad

Supervisor 2

2017

6 Synthesis of nitrogen heterocycles in the presence of magnetic nanoparticles and hydrogels, their cytotoxicity assessment and molecule modeling PhD / Organic Chemistry Faculty of Science, Zanjan University Supervisor 2 In progress
7 Synthesis and molecular modeling of new 3, 4 - dihydropyrimidin-2-one
derivatives as BACE-1 inhibitors
Pharm.D Hamadan School of Pharmacy Supervisor 2 2017
8 Study on the interaction of inorganic nano-drugs with protein via
computational methods
Msc / Organic Chemistry Imam Khomeini International University, Qazvin Advisor  2015
  • Design and modeling of potentially bioactive molecules using  molecular docking, SAR, QSAR, Ab initio and molecular dynamics
  • Synthesis of potentially bioactive heterocyclic compounds
  • Structure activity relationship study of heterocyclic compounds
  • Modern optimization of chemical & biological processes

Title

 Year
Top researcher of Ardabil University of Medical Sciences 2017
Top teacher of Ardabil University of Medical Sciences  2015
Top researcher of Ardabil University of Medical Sciences

2014

Top researcher of Ardabil University of Medical Sciences

2013

First rank of medicinal chemistry in PhD Entrance Exam (Ministry of Health)

2008

First rank (Top student) in PhD (Shiraz University of Medical Sciences)

Incoming 2008

First rank (Top student) in Msc (Amirkabir University of Technology)

Incoming 2001

 

Title

Place

Level

Date

Molecular Docking and its Application in Drug Design School of Pharmacy, Ardabil University of Medical Sciences National September 2018
Molecular Modeling School of Medicine, Hamadan University of Medical Sciences National October 2017
Molecular Docking and its Application in Drug Design School of Pharmacy, Ardabil University of Medical Sciences National August 2017
Molecular Docking and its Application in Drug Design School of Pharmacy, Ardabil University of Medical Sciences National August 2016
 Introduction to AutoDock software School of Pharmacy, Mazandaran University of Medical Sciences National November 2015
Molecular Docking and its Application in Drug Design School of Pharmacy, Ardabil University of Medical Sciences National September 2015
Molecular Docking and its Application in Drug Design School of Pharmacy, Kerman University of Medical Sciences National March 2015
Molecular Docking and its Application in Drug Design School of Pharmacy, Ardabil University of Medical Sciences National October 2014
Molecular Docking and its Application in Drug Design School of Pharmacy, Ardabil University of Medical Sciences National September 2014
Drug Design Faculty of Science, Islamic Azad University of Ahvaz National May 2014